Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 16/20 | 0.49 |
| ▸ | CTSB | P07858 | 15/20 | 0.49 |
| ▸ | CTSS | P25774 | 14/20 | 0.49 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576474 | 0.84 | CTSL (0.66) | CTSLCTSBCTSSCTSK | |
| SCHEMBL6053502 | 0.84 | CTSB (0.56) | CTSLCTSBCTSSCTSK | |
| SCHEMBL6053160 | 0.77 | CTSL (0.43) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4576471 | 0.76 | CTSL (0.44) | CTSLCTSBCTSSCTSK | |
| SCHEMBL6053232 | 0.73 | CTSB (0.59) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4576438 | 0.71 | CTSB (0.71) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4576013 | 0.69 | CTSB (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4576583 | 0.69 | CTSB (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4577125 | 0.69 | CTSB (0.73) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3912181 | 0.67 | CTSB (0.74) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651238-A1 | COMBINATIONS OF A CATHEPSIN K INHIBITOR AND A BISPHOPHONATE IN THE TREATMENT OF BONE METASTASIS, TUMOR GROWTH AND TUMOR-INDUCED BONE LOSS | Novartis AG (CH) | 2006-05-03 | — | — | EP | claimed |
| WO-2005014006-A1 | COMBINATIONS OF A CATHEPSIN K INHIBITOR AND A BISPHOPHONATE IN THE TREATMENT OF BONE METASTASIS, TUMOR GROWTH AND TUMOR-INDUCED BONE LOSS | NOVARTIS AG (CH) | 2005-02-17 | — | — | WO | claimed |