Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345865 | 0.88 | MET (0.60) | METHRH3PDK2ALKKCNH2 | |
| SCHEMBL2345863 | 0.88 | MET (0.60) | METHRH3PDK2ALKKCNH2 | |
| SCHEMBL2344325 | 0.81 | HRH3 (0.65) | METHRH3ALKKCNH2 | |
| SCHEMBL2344330 | 0.81 | HRH3 (0.65) | METHRH3ALKKCNH2 | |
| SCHEMBL2403402 | 0.80 | HRH3 (0.54) | METHRH3ALKKCNH2 | |
| SCHEMBL2340660 | 0.79 | MET (0.61) | METHRH3ALKKCNH2 | |
| SCHEMBL12393031 | 0.79 | MET (0.61) | METHRH3ALKKCNH2 | |
| Trifluoroacetic Acid SCHEMBL2340746 | 0.79 | ALK (0.58) | METHRH3PDK2ALKKCNH2 | |
| Trifluoroacetic Acid SCHEMBL2340751 | 0.79 | ALK (0.58) | METHRH3PDK2ALKKCNH2 | |
| SCHEMBL10293596 | 0.78 | HRH3 (0.62) | METHRH3ALKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735278-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097740-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | disclosed |