Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.51 |
| ▸ | PCNA | P12004 | 8/20 | 0.51 |
| ▸ | THRA | P10827 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086473 | 0.84 | THRB (0.61) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL6535482 | 0.82 | LMNA (0.40) | LMNAPOLBHPGDSMN1; SMN2MEN1 | |
| SCHEMBL7114999 | 0.77 | THRB (0.49) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL16124484 | 0.72 | THRB (0.77) | THRBPCNATHRALMNAPOLB | |
| Acetiromate SCHEMBL31231307 | 0.71 | TSHR (0.49) | THRBPCNATHRALMNAPOLB | |
| Acetiromate SCHEMBL2110761 | 0.71 | TSHR (0.49) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL9748136 | 0.71 | THRB (0.67) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL14575001 | 0.70 | THRB (0.54) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL3227547 | 0.69 | THRB (0.60) | THRBPCNATHRALMNAPOLB | |
| SCHEMBL16124483 | 0.68 | THRB (0.81) | THRBPCNATHRALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173163-B1 | PHARMACEUTICAL COMPOSITIONS OF TETRAC AND METHODS OF USE THEREOF | DANFORTH ELLIOT JR (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20040220269-A1 | Pharmaceutical compositions of tetrac and methods of use thereof | BEARTOWNPHARMA, INC. | 2004-11-04 | — | — | US | disclosed |
| US-6740680-B1 | SUPPRESSING THYROID STIMULATING HORMONE (TSH) SECRETION WITHOUT PITUITARY SPECIFIC MONODEIODINASE TYPE II INHIBITION | BECTON PHARMA, INC. | 2004-05-25 | — | — | US | disclosed |