Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | ACP1 | P24666 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.63 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.63 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.61 |
| ▸ | SGPL1 | O95470 | 2/20 | 0.40 |
| ▸ | YWHAG | P61981 | 1/20 | 0.38 |
| ▸ | YWHAZ | P63104 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727925 | 0.82 | ESR1 (0.69) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL30413789 | 0.82 | ESR1 (0.69) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL15387271 | 0.79 | PNPO (0.68) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL10906026 | 0.79 | ESR1 (0.66) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL20323319 | 0.79 | ESR1 (0.66) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL29384180 | 0.78 | ESR1 (0.64) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL43880 | 0.78 | ESR1 (0.64) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL13176882 | 0.78 | ESR1 (0.64) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| Pyridoxamine Phosphate Anhydrous SCHEMBL43832 | 0.77 | ESR1 (0.63) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| Pyridoxal Phosphate Anhydrous SCHEMBL23158 | 0.77 | P2RX2 (1.00) | ESR1PTGS1ACP1PDE4AP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030146-B2 | Methods for treating diabetic neuropathy | UNIVERSITY OF SOUTH CAROLINA (US) | 2006-04-18 | — | — | US | disclosed |
| US-20030181492-A1 | Methods for inhibiting diabetic complications | UNIVERSITY OF SOUTH CAROLINA | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181492-A1 | Methods for inhibiting diabetic complications | AGER, NOX4, NOX1 | ESR1 3597/4885PTGS1 369/4885ACP1 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.