Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786968 | 0.81 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL11529933 | 0.77 | L3MBTL1 (0.63) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8923438 | 0.76 | PPARA (0.44) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6054513 | 0.74 | SMN1; SMN2 (0.51) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL4322184 | 0.73 | KMT2A (0.57) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9787226 | 0.73 | MAPT (0.64) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8922021 | 0.72 | PPARA (0.49) | ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4859122 | 0.72 | MEN1 (0.69) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9119059 | 0.72 | MAPT (0.53) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL4397391 | 0.72 | HPN (0.53) | MAPTALDH1A1SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137948-B1 | METHODS AND COMPOSITIONS TO LOWER PLASMA CHOLESTEROL LEVELS | ATHEROGENICS INC (US) | 2006-05-10 | — | — | EP | disclosed |