Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.78 |
| ▸ | RAB9A | P51151 | 7/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12561353 | 0.89 | NPC1 (0.64) | NPC1RAB9AKMT2AFKBP5MEN1 | |
| SCHEMBL20083955 | 0.86 | KCNK3 (0.69) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL28622654 | 0.85 | RAB9A (0.93) | NPC1RAB9AKMT2AFKBP5MEN1 | |
| SCHEMBL8203978 | 0.85 | RAB9A (1.00) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL5172599 | 0.83 | KMT2A (0.68) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL6778190 | 0.82 | KMT2A (0.71) | NPC1RAB9AKMT2AFKBP5MEN1 | |
| SCHEMBL4701359 | 0.82 | KMT2A (0.71) | NPC1RAB9AKMT2AFKBP5MEN1 | |
| SCHEMBL4122903 | 0.82 | NPC1 (0.71) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL23657657 | 0.82 | NPC1 (0.67) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL28025774 | 0.81 | NPC1 (0.64) | NPC1RAB9AKMT2AFKBP5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682181-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | Novartis AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005027972-A2 | COMBINATION OF A VEGF RECEPTOR INHIBITOR WITH A CHEMOTHERAPEUTIC AGENT | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |