Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6057742 | 0.80 | POLB (0.45) | POLBPTGER4MAPK8LCKLMNA | |
| SCHEMBL6057807 | 0.79 | LCK (0.54) | LCK | |
| SCHEMBL6057945 | 0.74 | LCK (0.56) | LCK | |
| SCHEMBL6058429 | 0.73 | LCK (0.61) | LCK | |
| SCHEMBL7176198 | 0.73 | POLB (0.54) | POLBPTGER4MAPK8LCKLMNA | |
| SCHEMBL7631673 | 0.73 | LCK (0.46) | PTGER4LCKLMNATP53RXFP1 | |
| SCHEMBL7826823 | 0.72 | POLB (0.76) | POLBPTGER4MAPK8LCKLMNA | |
| SCHEMBL6058008 | 0.68 | LCK (0.56) | LCKLMNATP53 | |
| SCHEMBL6057754 | 0.68 | MEN1 (0.53) | POLBLCKLMNAMEN1KMT2A | |
| SCHEMBL1894942 | 0.68 | CYP1A2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-B1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2006-01-11 | — | — | EP | claimed |