SCHEMBL6057945

SCHEMBL6057945

Cc1cc(C)c(NC(=O)c2ccc3s[c]nc3c2)c(C)c1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LCK P06239 19/20 0.56
PKM P14618 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6058429 0.91 LCK (0.61) LCK
SCHEMBL6058008 0.81 LCK (0.56) LCK
SCHEMBL6057508 0.79 LCK (0.69) LCK
SCHEMBL31680606 0.76 PKM (0.68) LCKPKM
SCHEMBL6057789 0.74 POLB (0.45) LCK
SCHEMBL6057742 0.74 POLB (0.45) LCK
SCHEMBL7628412 0.74 NPC1 (0.62) LCK
SCHEMBL6057811 0.73 LCK (0.84) LCK
SCHEMBL6364831 0.73 NPC1 (0.54)
SCHEMBL3048923 0.73 CA12 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037632-B1 BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2006-01-11 EP claimed