Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766676 | 1.00 | ADAMTS5 (0.62) | ADAMTS5MAPTHTTALDH1A1HPGD | |
| SCHEMBL2766673 | 1.00 | ADAMTS5 (0.62) | ADAMTS5MAPTHTTALDH1A1HPGD | |
| SCHEMBL2764133 | 0.87 | ADAMTS5 (0.59) | ADAMTS5MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6058936 | 0.87 | ADAMTS5 (0.59) | ADAMTS5MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL2764130 | 0.87 | ADAMTS5 (0.59) | ADAMTS5MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL2764975 | 0.83 | ADAMTS5 (0.65) | ADAMTS5MAPTALDH1A1NPC1KDM4E | |
| SCHEMBL2764179 | 0.81 | ADAMTS5 (0.86) | ADAMTS5MAPTHTTMEN1KMT2A | |
| SCHEMBL2764182 | 0.81 | ADAMTS5 (0.86) | ADAMTS5MAPTHTTMEN1KMT2A | |
| SCHEMBL5495201 | 0.81 | ADAMTS5 (0.64) | ADAMTS5KDM4ENPSR1 | |
| SCHEMBL2763654 | 0.81 | ADAMTS5 (0.64) | ADAMTS5KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | disclosed |