Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.64 |
| ▸ | GHSR | Q92847 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763655 | 1.00 | ADAMTS5 (0.64) | ADAMTS5GHSRMAPK1CYP2C19MMP1 | |
| SCHEMBL2763654 | 1.00 | ADAMTS5 (0.64) | ADAMTS5GHSRMAPK1CYP2C19MMP1 | |
| SCHEMBL5494344 | 0.83 | ADAMTS5 (0.69) | ADAMTS5GHSRMAPK1CYP2C19MMP1 | |
| SCHEMBL2765675 | 0.83 | ADAMTS5 (0.69) | ADAMTS5GHSRMAPK1CYP2C19MMP1 | |
| SCHEMBL2765671 | 0.83 | ADAMTS5 (0.69) | ADAMTS5GHSRMAPK1CYP2C19MMP1 | |
| SCHEMBL2764182 | 0.82 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP1MMP14 | |
| SCHEMBL2764179 | 0.82 | ADAMTS5 (0.86) | ADAMTS5MAPK1CYP2C19MMP1MMP14 | |
| SCHEMBL6058640 | 0.81 | ADAMTS5 (0.62) | ADAMTS5KDM4ENPSR1 | |
| SCHEMBL2766676 | 0.81 | ADAMTS5 (0.62) | ADAMTS5KDM4ENPSR1 | |
| SCHEMBL2766673 | 0.81 | ADAMTS5 (0.62) | ADAMTS5KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516982-A | — | — | 2007-06-28 | — | — | JP | claimed |
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | claimed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | claimed |