Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990594 | 0.83 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1PKMMAPTKDM4E | |
| SCHEMBL12764466 | 0.83 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1PKMMAPTKDM4E | |
| SCHEMBL1088524 | 0.82 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL26090256 | 0.82 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL6219928 | 0.82 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL1189317 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2USP2ALDH1A1MAPTKDM4E | |
| SCHEMBL10246530 | 0.79 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL22615133 | 0.79 | MAPT (0.51) | SMN1; SMN2USP2ALDH1A1PKMMAPT | |
| SCHEMBL1456654 | 0.78 | CHRM2 (0.38) | CHRM2CHRM4CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL22284409 | 0.78 | GPR119 (0.44) | ALDH1A1PKMKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |