Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 8/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.44 |
| ▸ | THRA | P10827 | 6/20 | 0.44 |
| ▸ | THRB | P10828 | 6/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6060414 | 0.85 | EGLN1 (0.55) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL6061538 | 0.85 | DHODH (0.45) | SLC6A2IGFBP3 | |
| SCHEMBL522902 | 0.81 | EGLN2 (0.41) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL6061140 | 0.80 | EGLN1 (0.54) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL27653611 | 0.80 | DHODH (0.45) | SLC6A2IGFBP3 | |
| SCHEMBL12955452 | 0.77 | EGLN1 (0.52) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL524231 | 0.77 | EGLN1 (0.40) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL523237 | 0.75 | EGLN1 (0.71) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL5934937 | 0.75 | EGLN1 (0.51) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL523801 | 0.74 | THRA (0.79) | EGLN2EGLN1THRATHRBBBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |