Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.55 |
| ▸ | THRA | P10827 | 9/20 | 0.55 |
| ▸ | THRB | P10828 | 9/20 | 0.55 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | ASPH | Q12797 | 1/20 | 0.54 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.54 |
| ▸ | EGLN2 | Q96KS0 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061140 | 0.94 | EGLN1 (0.54) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL25865982 | 0.87 | EGLN1 (0.54) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL14672078 | 0.86 | EGLN1 (0.71) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523237 | 0.86 | EGLN1 (0.71) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL6060367 | 0.85 | EGLN2 (0.47) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL28426854 | 0.84 | THRA (0.56) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL22441929 | 0.84 | THRA (0.59) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL24130774 | 0.83 | THRA (0.59) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL522886 | 0.83 | EGLN1 (0.64) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL6060762 | 0.83 | EGLN1 (0.65) | EGLN1THRATHRBBBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |