Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 9/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 4/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061166 | 0.93 | EGLN1 (0.58) | EGLN2EGLN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6060700 | 0.84 | EGLN2 (0.50) | EGLN2EGLN1 | |
| SCHEMBL4958619 | 0.84 | EGLN1 (0.70) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL23269742 | 0.82 | EGLN1 (0.76) | EGLN2EGLN1 | |
| SCHEMBL1115578 | 0.78 | EGLN1 (0.67) | EGLN2EGLN1THRATHRBBBOX1 | |
| SCHEMBL19808941 | 0.78 | EGLN1 (0.74) | EGLN1SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL522601 | 0.76 | THRA (0.60) | EGLN2EGLN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL523583 | 0.76 | EGLN1 (0.62) | EGLN2EGLN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4075055 | 0.76 | EGLN2 (0.52) | EGLN2EGLN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL6059867 | 0.76 | EGLN1 (0.52) | EGLN2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |