Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyproterone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | PGR known ✓ | P06401 | 7/20 | 1.00 |
| ▸ | AR known ✓ | P10275 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyproterone Acetate SCHEMBL21540064 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL11801394 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL8021230 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL11795995 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL15780914 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL20459065 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL5936 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL9800274 | 1.00 | NR3C1 (1.00) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL7857093 | 0.98 | NR3C1 (0.96) | NR3C1CYP3A4PGRARLMNA | |
| Cyproterone Acetate SCHEMBL7867230 | 0.97 | NR3C1 (0.94) | NR3C1CYP3A4PGRARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641458-A2 | PHARMACEUTICAL COMBINATIONS OF PHTHALAZINE VEGF INHIBITORS AND BENZAMIDE HDAC INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-04-05 | — | — | EP | claimed |
| WO-2004058234-A2 | PHARMACEUTICAL COMBINATIONS OF PHTHALAZINE VEGF INHIBITORS AND BENZAMIDE HDAC INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-07-15 | — | — | WO | claimed |
| EP-0136465-B1 | Process for the preparation of 17-alpha-acetoxy-1-alpha, 2-alpha-methylene-pregna-4,6-diene-3,20 dione | SCHERING AG (DE) | 1995-05-17 | — | — | EP | disclosed |
| US-4599200-A | Process for the production of 17α-acetoxy-1α,2α-methylene-4,6-pregnadiene-3,20-dione | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-07-08 | — | — | US | disclosed |
| EP-0136465-A2 | Process for the preparation of 17-alpha-acetoxy-1-alpha, 2-alpha-methylene-pregna-4,6-diene-3,20 dione | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-04-10 | — | — | EP | disclosed |