SCHEMBL6062153

SCHEMBL6062153

O=C(CCCCNC(=O)C(CS(=O)(=O)Cc1ccccc1C(F)(F)F)CS(=O)(=O)Cc1ccccc1C(F)(F)F)c1nc2ccccc2o1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAGLA Q9Y4D2 6/20 0.43
FAAH O00519 3/20 0.43
CES1 P23141 2/20 0.43
PTPN1 P18031 2/20 0.40
RBP4 P02753 1/20 0.36
HSPD1 P10809 1/20 0.35
PTPN2 P17706 1/20 0.35
PTPN5 P54829 1/20 0.35
HSPE1 P61604 1/20 0.35
HDAC6 Q9UBN7 4/20 0.35
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35
LIPG Q9Y5X9 1/20 0.34
HDAC3 O15379 2/20 0.34
HDAC4 P56524 2/20 0.34
HDAC1 Q13547 2/20 0.34
HDAC7 Q8WUI4 2/20 0.34
HDAC2 Q92769 2/20 0.34
HDAC10 Q969S8 2/20 0.34
HDAC11 Q96DB2 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6062834 0.85 DAGLA (0.56) DAGLAFAAHCES1
SCHEMBL6636292 0.82 DAGLA (0.45) DAGLAFAAHCES1HDAC6MTNR1A
SCHEMBL5418131 0.79 CTSS (0.43) PTPN1CTSLCTSSCTSK
SCHEMBL6062448 0.78 FAAH (0.38) DAGLAFAAHCES1PTPN1RBP4
SCHEMBL7045344 0.76 FAAH (0.41) DAGLAFAAHCES1HDAC6MTNR1A
SCHEMBL6061878 0.76 DAGLA (0.47) DAGLAFAAHCES1CTSS
SCHEMBL6630032 0.75 DAGLA (0.40) DAGLAFAAHCES1HDAC6MTNR1A
SCHEMBL6062952 0.74 DAGLA (0.52) DAGLAFAAHCES1MTNR1AMTNR1B
SCHEMBL6631047 0.74 DAGLA (0.52) DAGLAFAAHCES1HDAC6
SCHEMBL6630749 0.74 DAGLA (0.53) DAGLAFAAHCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383748-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-01-28 EP claimed
WO-2002051983-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-07-04 WO claimed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed