Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 9/20 | 0.49 |
| ▸ | CTSB | P07858 | 8/20 | 0.49 |
| ▸ | CTSH | P09668 | 5/20 | 0.49 |
| ▸ | CTSK | P43235 | 16/20 | 0.49 |
| ▸ | CTSS | P25774 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062781 | 1.00 | CTSL (0.49) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6063204 | 0.88 | CTSL (0.47) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6063198 | 0.88 | CTSL (0.47) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6062404 | 0.84 | CTSL (0.50) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6062399 | 0.84 | CTSL (0.50) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6063058 | 0.83 | CTSL (0.51) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6062157 | 0.83 | CTSL (0.54) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6063052 | 0.83 | CTSL (0.51) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6062159 | 0.83 | CTSL (0.54) | CTSLCTSBCTSHCTSKCTSS | |
| SCHEMBL6696109 | 0.82 | CTSK (0.60) | CTSLCTSBCTSHCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |