SCHEMBL6062871

SCHEMBL6062871

N#Cc1ccccc1N[C@@H](CC1CCCCC1)C(=O)NCCCC(=O)c1nc2ccccc2o1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CTSS P25774 15/20 0.53
CTSL P07711 10/20 0.44
CTSK P43235 4/20 0.42
FAAH O00519 3/20 0.39
CES1 P23141 2/20 0.39
DAGLA Q9Y4D2 1/20 0.39
CTSB P07858 1/20 0.39
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP3 P08254 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6062875 1.00 CTSS (0.53) CTSSCTSLCTSKFAAHCES1
SCHEMBL6062867 0.82 CTSS (0.46) CTSSCTSL
SCHEMBL6635584 0.80 CTSS (0.51) CTSSCTSLCTSKFAAHCES1
SCHEMBL6062976 0.76 CTSS (0.46) CTSSCTSLCTSKFAAHCES1
SCHEMBL6063245 0.75 CTSS (0.45) CTSSCTSLCTSKFAAHCES1
SCHEMBL6061878 0.72 DAGLA (0.47) CTSSFAAHCES1DAGLAMMP1
SCHEMBL6061894 0.70 FAAH (0.42) CTSSFAAHCES1DAGLA
SCHEMBL6062624 0.70 FAAH (0.42) CTSSFAAHCES1DAGLA
SCHEMBL5372166 0.70 CTSS (1.00) CTSSCTSLCTSK
SCHEMBL5372171 0.70 CTSS (1.00) CTSSCTSLCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed