Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.38 |
| ▸ | CTSB | P07858 | 12/20 | 0.38 |
| ▸ | CTSL | P07711 | 11/20 | 0.38 |
| ▸ | CTSK | P43235 | 9/20 | 0.38 |
| ▸ | CTSV | O60911 | 3/20 | 0.36 |
| ▸ | CTSF | Q9UBX1 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424530 | 0.87 | CTSS (0.49) | CTSSCTSBCTSLCTSKCTSV | |
| SCHEMBL6063001 | 0.83 | CTSS (0.38) | CTSSCTSBCTSLCTSKCTSF | |
| SCHEMBL5418134 | 0.82 | CTSS (0.45) | CTSSCTSBCTSLCTSKCTSV | |
| SCHEMBL5416025 | 0.82 | CTSS (0.48) | CTSSCTSBCTSLCTSKCTSV | |
| SCHEMBL5418091 | 0.79 | CTSS (0.43) | CTSSCTSBCTSLCTSKCTSV | |
| SCHEMBL5421069 | 0.79 | CTSS (0.42) | CTSSCTSBCTSLCTSK | |
| SCHEMBL5418267 | 0.78 | CTSS (0.43) | CTSSCTSBCTSLCTSK | |
| SCHEMBL6062041 | 0.73 | CTSC (0.41) | CTSSCTSBCTSLCTSK | |
| SCHEMBL5426376 | 0.73 | CTSS (0.60) | CTSSCTSBCTSLCTSKCTSV | |
| SCHEMBL6651832 | 0.72 | CTSS (0.40) | CTSSCTSBCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |