Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.38 |
| ▸ | CTSK | P43235 | 6/20 | 0.38 |
| ▸ | CTSB | P07858 | 11/20 | 0.37 |
| ▸ | CTSL | P07711 | 8/20 | 0.37 |
| ▸ | CTSF | Q9UBX1 | 5/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6063005 | 0.83 | CTSS (0.38) | CTSSCTSKCTSBCTSLCTSF | |
| SCHEMBL5418267 | 0.81 | CTSS (0.43) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5424530 | 0.79 | CTSS (0.49) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5421069 | 0.78 | CTSS (0.42) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5416025 | 0.77 | CTSS (0.48) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5418134 | 0.76 | CTSS (0.45) | CTSSCTSKCTSBCTSL | |
| SCHEMBL6062041 | 0.76 | CTSC (0.41) | CTSSCTSKCTSBCTSL | |
| SCHEMBL6629347 | 0.75 | CTSS (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL6651832 | 0.75 | CTSS (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL6744795 | 0.74 | CTSL (0.57) | CTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |