Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1949239 | 0.90 | SLC6A1 (0.50) | PPM1BPTPN1PPP1CCMAPTTSHR | |
| SCHEMBL30376402 | 0.90 | GNAI3 (0.42) | MAPTPKMGNAI3GNAO1GNAI1 | |
| SCHEMBL3002273 | 0.90 | GNAI3 (0.42) | MAPTPKMGNAI3GNAO1GNAI1 | |
| SCHEMBL294366 | 0.89 | PPM1B (0.47) | PPM1BPTPN1PPP1CCMAPTGNAI3 | |
| Hydrochloric Acid SCHEMBL28953272 | 0.87 | PPM1B (0.46) | PPM1BPTPN1PPP1CCMAPTGNAI3 | |
| SCHEMBL11848695 | 0.87 | GNAI3 (0.47) | GNAI3GNAO1GNAI1TSHRSMN1; SMN2 | |
| SCHEMBL13610202 | 0.87 | GNAI3 (0.47) | GNAI3GNAO1GNAI1TSHRSMN1; SMN2 | |
| SCHEMBL2235927 | 0.85 | MAPT (0.49) | MAPTPKMTSHRGABRA5GABRB2 | |
| SCHEMBL12994147 | 0.85 | MAPT (0.49) | MAPTPKMTSHRGABRA5GABRB2 | |
| SCHEMBL8224141 | 0.85 | MAPT (0.49) | MAPTPKMTSHRGABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |