SCHEMBL6063780

SCHEMBL6063780

O=C(CCS(=O)(=O)Cc1ccccc1OC(F)F)NCCCC(=O)c1nc2ccccc2o1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FAAH O00519 3/20 0.41
DAGLA Q9Y4D2 3/20 0.41
CES1 P23141 2/20 0.41
GAA P10253 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
MTNR1A P48039 3/20 0.36
MTNR1B P49286 3/20 0.36
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35
KMT2A Q03164 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP2C19 P33261 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
SLC40A1 Q9NP59 1/20 0.34
XDH P47989 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6630032 0.87 DAGLA (0.40) FAAHDAGLACES1MTNR1AMTNR1B
SCHEMBL6699229 0.82 CTSS (0.45) CYP3A4CYP2C9ALDH1A1
SCHEMBL6636292 0.82 DAGLA (0.45) FAAHDAGLACES1MTNR1AMTNR1B
SCHEMBL6466177 0.79 DAGLA (0.44) FAAHDAGLACES1MTNR1AMTNR1B
SCHEMBL3622457 0.79 FAAH (0.35) FAAHDAGLACES1RAB9ANPC1
SCHEMBL3613204 0.79 FAAH (0.35) FAAHDAGLACES1CYP3A4CYP2C9
SCHEMBL3613201 0.78 FAAH (0.36) FAAHDAGLACES1CYP3A4CYP2C9
SCHEMBL3622455 0.77 FAAH (0.35) FAAHDAGLACES1RAB9ANPC1
SCHEMBL6465216 0.76 FAAH (0.39) FAAHDAGLACES1CYP2C9CYP2C19
SCHEMBL6467763 0.75 FAAH (0.36) FAAHDAGLACES1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed