Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31634333 | 0.83 | GRIK1 (0.41) | GRIK1GRIK2ESR1ESR2SLC5A1 | |
| SCHEMBL11045229 | 0.83 | GRIK1 (0.41) | GRIK1GRIK2ESR1ESR2SLC5A1 | |
| SCHEMBL7631405 | 0.81 | CYP2C19 (0.42) | GRIK1GRIK2HDAC1HDAC8ESR1 | |
| SCHEMBL7631408 | 0.81 | CYP2C19 (0.42) | GRIK1GRIK2HDAC1HDAC8ESR1 | |
| SCHEMBL2089300 | 0.77 | HSD17B10 (0.45) | GRIK1GRIK2HIF1ATRPV1 | |
| SCHEMBL97322 | 0.76 | PAM (0.48) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL22245646 | 0.76 | PAM (0.48) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL97508 | 0.75 | GRIK1 (0.44) | GRIK1GRIK2ESR1ESR2SLC5A1 | |
| SCHEMBL14401828 | 0.74 | TNNC1 (0.43) | GRIK1GRIK2ALDH1A1RAB9ALMNA | |
| SCHEMBL29278715 | 0.74 | GRIK1 (0.41) | GRIK1GRIK2HDAC1HDAC8ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638544-A2 | KETONES AND REDUCED KETONES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS | The University Court of The University of Aberdeen (GB) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004098582-A2 | KETONES AND REDUCED KETONES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2004-11-18 | — | — | WO | disclosed |