Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.57 |
| ▸ | CTSB | P07858 | 5/20 | 0.51 |
| ▸ | CTSL | P07711 | 4/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSH | P09668 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023913 | 0.85 | CTSS (0.57) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL5438934 | 0.85 | CTSS (0.57) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL3023908 | 0.85 | CTSS (0.57) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7656003 | 0.85 | CTSS (0.55) | CTSSCTSBCTSLCTSK | |
| SCHEMBL7655999 | 0.85 | CTSS (0.55) | CTSSCTSBCTSLCTSK | |
| SCHEMBL6848124 | 0.81 | CTSS (0.55) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL6848353 | 0.80 | CTSS (0.54) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14491117 | 0.79 | CTSS (0.53) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL6848129 | 0.79 | CTSS (0.53) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL5443847 | 0.79 | CTSS (0.53) | CTSSCTSBCTSLCTSKCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |