Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.70 |
| ▸ | PPARA | Q07869 | 4/20 | 0.70 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064465 | 1.00 | PPARG (0.70) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL11846589 | 0.98 | PPARG (0.73) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL11846594 | 0.98 | PPARG (0.73) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL21715540 | 0.94 | PPARG (0.69) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL16177712 | 0.93 | PPARG (0.61) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL16177715 | 0.93 | PPARG (0.61) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL2599317 | 0.91 | PPARG (0.82) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL6448401 | 0.91 | PPARG (0.82) | PPARGPPARATRPA1KDM4EPOLB | |
| SCHEMBL8593649 | 0.89 | PPARG (0.86) | PPARGPPARAKDM4EPOLBTERT | |
| SCHEMBL8698253 | 0.89 | PPARG (0.79) | PPARGPPARAKDM4EPOLBTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638913-A1 | PROCESSES FOR PREPARING BETA-HYDROXY-KETONES AND ALPHA, BETA-UNSATURATED KETONES | EASTMAN CHEMICAL COMPANY (US) | 2006-03-29 | — | — | EP | claimed |
| US-6960694-B2 | Processes for preparing β-hydroxy-ketones and α,β-unsaturated ketones | EASTMAN CHEMICAL COMPANY (US) | 2005-11-01 | — | — | US | claimed |
| WO-2005005361-A1 | PROCESSES FOR PREPARING BETA-HYDROXY-KETONES AND ALPHA, BETA-UNSATURATED KETONES | EASTMAN CHEMICAL COMPANY (US) | 2005-01-20 | — | — | WO | claimed |
| US-20050004401-A1 | Processes for preparing beta-hydroxy-ketones and alpha,beta-unsaturated ketones | EASTMAN CHEMICAL COMPANY | 2005-01-06 | — | — | US | claimed |
| US-8304581-B2 | Method of enantioselective addition to enones | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-11-06 | — | — | US | disclosed |
| US-20110282101-A1 | METHOD OF ENANTIOSELECTIVE ADDITION TO ENONES | NATIONAL TSING HUA UNIVERSITY (TW) | 2011-11-17 | — | — | US | disclosed |
| US-5583263-A | REACTING ACETONE AND BUTYRALDEHYDE IN PRESENCE OF FIXED BED BASIC ION EXCHANGE CROSS ALDOL CATALYST AND WATER, DEHYDRATING IN PRESENCE OF STEAM AND ACID CATALYST, HYDROGENATING TO MIXTURE OF AMYL AND ISOBUTYL METHYL KETONES | SHELL OIL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| US-4212825-A | Aldol condensation and hydrogenation process using a catalyst of nickel and cobalt together with zinc oxide and another metal of groups VIII, IIb, IIIa, IVa and Va of the periodic table | BASF AKTIENGESELLSCHAFT (DE) | 1980-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282101-A1 | METHOD OF ENANTIOSELECTIVE ADDITION TO ENONES | CPNE4, ENY2, CYP3A4 | PPARG 2432/4885PPARA 2719/4885TRPA1 4725/4885 |
| US-20050004401-A1 | Processes for preparing beta-hydroxy-ketones and alpha,beta-unsaturated ketones | EBP, CYP8B1, BCKDK | PPARG 776/4885PPARA 341/4885TRPA1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.