Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.82 |
| ▸ | PPARA | Q07869 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | TERT | O14746 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | FABP4 | P15090 | 2/20 | 0.59 |
| ▸ | FAAH | O00519 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PPARD | Q03181 | 2/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599317 | 1.00 | PPARG (0.82) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL29120297 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL8593649 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL18489891 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL812752 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL812753 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL8460772 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL8593645 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL28945778 | 0.98 | PPARG (0.86) | PPARGPPARAKDM4ETERTPTPN1 | |
| SCHEMBL26968801 | 0.96 | PPARG (0.83) | PPARGPPARAKDM4ETERTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115624544-A | Application of chalcone analogue as active substance in preparation of antitumor drugs | 甘肃中医药大学 | 2023-01-20 | — | — | CN | disclosed |
| US-11413278-B2 | Compounds and methods for promoting stress resistance | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-16 | — | — | US | disclosed |
| US-20180289682-A1 | COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-10-11 | — | — | US | disclosed |
| EP-2571843-B1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2017-12-27 | — | — | EP | disclosed |
| CN-104803927-B | Chalcone analog of the base containing 2 methyl, 4 oxoquinazolin 6 and its production and use | 首都师范大学 | 2017-11-07 | — | — | CN | disclosed |
| WO-2017062751-A1 | COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-13 | — | — | WO | disclosed |
| CN-104803927-A | Chalcone analogue containing 2-methyl-4-oxo-quinazoline-6-base, and preparation method and application thereof | UNIV CAPITAL NORMAL | 2015-07-29 | — | — | CN | disclosed |
| US-8765992-B2 | Preparation of chalcone derivatives | GENFIT (FR) | 2014-07-01 | — | — | US | disclosed |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20050203170-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | AVENTIS PHARMA S.A. | 2005-09-15 | — | — | US | disclosed |
| US-20040147597-A1 | Anti-mycobacterium compositions and methods of preparing and using same | ADVANCED LIFE SCIENCES, INC. | 2004-07-29 | — | — | US | disclosed |
| US-20040147584-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | US | disclosed |
| WO-2003048106-A3 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2004-03-25 | — | — | WO | disclosed |
| US-6677350-B1 | ADMINISTERING CHALCONE-LIKE VINYLCARBONYL COMPOUNDS TO PREVENT OR TREAT MYCOBACTERIUM INFECTIONS/TUBERCULOSIS | ADVANCED LIFE SCIENCES, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | AVENTIS PHARMA S.A. | 2003-08-14 | — | — | US | disclosed |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | AVENTIS PHARMA S.A. | 2003-08-14 | — | — | US | disclosed |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | AVENTIS PHARMA S.A. | 2003-08-14 | — | — | US | disclosed |
| WO-2003048106-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2003-06-12 | — | — | WO | disclosed |
| EP-1217995-A2 | ANTI-MYCOBACTERIUM COMPOSITIONS AND METHODS OF PREPARING AND USING SAME | Advanced Life Sciences Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021164-A2 | ANTI-MYCOBACTERIUM COMPOSITIONS AND METHODS OF PREPARING AND USING SAME | ADVANCED LIFE SCIENCES, INC. (US) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147584-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | MCL1, ENPP1, MYC | PPARG 2299/4885PPARA 1360/4885KDM4E 1899/4885 |
| US-20180289682-A1 | COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE | HSPA9, ATF4, GPX4 | PPARG 1199/4885PPARA 1380/4885KDM4E 4057/4885 |
| US-20040147597-A1 | Anti-mycobacterium compositions and methods of preparing and using same | IMMT, CYP51A1, LSS | PPARG 410/4885PPARA 955/4885KDM4E 2116/4885 |
| US-20050203170-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | MCL1, ENPP1, MYC | PPARG 2299/4885PPARA 1360/4885KDM4E 1899/4885 |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | SULT1E1, HCCS, STS | PPARG 1812/4885PPARA 1760/4885KDM4E 838/4885 |
| US-11413278-B2 | Compounds and methods for promoting stress resistance | HSPA9, ATF4, GPX4 | PPARG 1199/4885PPARA 1380/4885KDM4E 4057/4885 |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | MCL1, ENPP1, MYC | PPARG 2299/4885PPARA 1360/4885KDM4E 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.