Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 10/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28859609 | 0.79 | APLNR (0.54) | APLNRLMNAKDM4CCYP1A2CYP3A4 | |
| SCHEMBL20157650 | 0.77 | APLNR (0.51) | APLNRLMNAGAAKDM4CL3MBTL1 | |
| SCHEMBL29850829 | 0.74 | ERN1 (0.53) | LMNACYP1A2CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL18124571 | 0.71 | APLNR (0.68) | APLNRLMNATSHRMEN1KMT2A | |
| SCHEMBL28358946 | 0.71 | KDM4C (0.47) | APLNRLMNAGAAKDM4CL3MBTL1 | |
| SCHEMBL29551875 | 0.71 | KDM4C (0.52) | APLNRLMNAGAAKDM4CCYP1A2 | |
| SCHEMBL29922806 | 0.71 | KDM4C (0.47) | APLNRLMNAGAAKDM4CL3MBTL1 | |
| SCHEMBL15435400 | 0.70 | GAA (0.54) | APLNRLMNAGAAKDM4CL3MBTL1 | |
| SCHEMBL20511323 | 0.70 | APLNR (0.56) | APLNRLMNAGAAKDM4CCYP1A2 | |
| SCHEMBL15435347 | 0.69 | APLNR (0.51) | APLNRLMNAGAAKDM4CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667973-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030792-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |