Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.53 |
| ▸ | TSHR | P16473 | 10/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14868265 | 0.83 | APLNR (0.56) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL14868266 | 0.81 | APLNR (0.61) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL14868267 | 0.80 | APLNR (0.59) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL5543274 | 0.79 | APLNR (0.58) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL12292182 | 0.79 | APLNR (0.58) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL21262083 | 0.79 | CYP1A2 (0.59) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL14671911 | 0.79 | GAA (0.70) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL24636086 | 0.78 | APLNR (0.56) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL16097759 | 0.77 | APLNR (0.52) | APLNRCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL4120083 | 0.77 | TSHR (0.43) | APLNRCYP1A2CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486258-B2 | Compounds and methods for regulating insulin secretion | THE BROAD INSTITUTE, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | THE BROAD INSTITUTE, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | THE BROAD INSTITUTE, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-11555031-B2 | Compounds and methods for regulating insulin secretion | THE BROAD INSTITUTE, INC. (US) | 2023-01-17 | — | — | US | disclosed |
| EP-3601326-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | The Broad Institute, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018175324-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | THE BROAD INSTITUTE, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | IAPP, GPR119, PNLIP | APLNR 246/4885CYP1A2 4816/4885CYP3A4 4626/4885 |
| US-11555031-B2 | Compounds and methods for regulating insulin secretion | IAPP, GPR119, INSR | APLNR 607/4885CYP1A2 3527/4885CYP3A4 2639/4885 |
| US-12486258-B2 | Compounds and methods for regulating insulin secretion | IAPP, GPR119, PNLIP | APLNR 246/4885CYP1A2 4816/4885CYP3A4 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.