Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 2/20 | 0.45 |
| ▸ | FPR3 | P25089 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065156 | 1.00 | RAB9A (0.52) | RAB9APOLBHTTPTPN2PTPN1 | |
| SCHEMBL4445653 | 0.85 | F10 (0.51) | POLBHTTPTPN2PTPN1PTPN6 | |
| SCHEMBL6065732 | 0.85 | F10 (0.51) | POLBHTTPTPN2PTPN1PTPN6 | |
| SCHEMBL2202193 | 0.82 | FPR2 (0.51) | PTPN2PTPN1PTPN6ALDH1A1FPR2 | |
| SCHEMBL17729066 | 0.79 | PTPN2 (0.56) | RAB9APOLBPTPN2PTPN1PTPN6 | |
| SCHEMBL1751821 | 0.79 | PDE4B (0.58) | STSMEN1KMT2ANPSR1 | |
| SCHEMBL12592456 | 0.79 | PDE4B (0.58) | STSMEN1KMT2ANPSR1 | |
| SCHEMBL1267217 | 0.79 | PDE4B (0.58) | STSMEN1KMT2ANPSR1 | |
| SCHEMBL8283575 | 0.79 | PTPN2 (0.81) | RAB9AHTTPTPN2PTPN1PTPN6 | |
| SCHEMBL1015010 | 0.79 | PDE4B (0.58) | STSMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732918-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092881-A1 | NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | disclosed |