Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6066632 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL6067212 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL6066937 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL6067274 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL6448007 | 0.57 | — | — | |
| Hydrochloric Acid SCHEMBL6067327 | 0.57 | — | — | |
| SCHEMBL31656350 | 0.53 | TSHR (0.68) | RAB9AMAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL19687711 | 0.52 | ALDH1A1 (0.56) | RAB9AMAPTLMNATSHRRECQL | |
| SCHEMBL24724740 | 0.51 | ALDH1A1 (0.46) | RAB9AMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL29151538 | 0.51 | CYP2C19 (0.68) | RAB9AMAPTTSHRHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148173-B2 | Catalytic systems for the polymerization and copolymerization of alpha-olefins | REPSOL QUIMICA, S.A. (ES) | 2006-12-12 | — | — | US | claimed |
| US-7148173-B2 | Catalytic systems for the polymerization and copolymerization of alpha-olefins | REPSOL QUIMICA, S.A. (ES) | 2006-12-12 | — | — | US | disclosed |
| EP-0953581-B1 | Catalytic systems for the polymerization and copolymerization of alpha-olefins | REPSOL QUIMICA SA (ES) | 2004-01-07 | — | — | EP | disclosed |
| US-20030191013-A1 | CATALYTIC SYSTEMS FOR THE POLYMERIZATION AND COPOLYMERIZATION OF ALPHA-OLEFINS | REPSOL QUIMICA S.A. (ES) | 2003-10-09 | — | — | US | disclosed |
| EP-0953581-A1 | Catalytic systems for the polymerization and copolymerization of alpha-olefins | REPSOL QUIMICA S.A. (ES) | 1999-11-03 | — | — | EP | disclosed |