Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065 | 1.00 | HTT (0.45) | HTTMEN1KMT2ATRPV1GAA | |
| SCHEMBL11909292 | 0.88 | HTT (0.49) | HTTMEN1KMT2AGAAMAPK1 | |
| SCHEMBL11909294 | 0.88 | HTT (0.49) | HTTMEN1KMT2AGAAMAPK1 | |
| SCHEMBL2014265 | 0.86 | MEN1 (0.45) | HTTMEN1KMT2AGAAMAPT | |
| SCHEMBL13834569 | 0.86 | MEN1 (0.45) | HTTMEN1KMT2AGAAMAPT | |
| SCHEMBL5906 | 0.85 | NPY5R (0.42) | KMT2AMAPK1MAPTL3MBTL1 | |
| SCHEMBL6903 | 0.85 | KAT2B (0.43) | HTTMEN1KMT2AMAPK1MAPT | |
| SCHEMBL6123 | 0.85 | NPY5R (0.42) | MAPK1MAPTCCR3ALDH1A1LMNA | |
| SCHEMBL6263 | 0.85 | KAT2B (0.44) | HTTMEN1KMT2ATRPV1GAA | |
| SCHEMBL5904 | 0.85 | NPY5R (0.42) | KMT2AMAPK1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |