Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904 | 1.00 | NPY5R (0.42) | NPY5RFASNMAPK1EPHX2L3MBTL1 | |
| SCHEMBL6121 | 0.92 | NPY5R (0.42) | NPY5RFASNMAPK1EPHX2ACHE | |
| SCHEMBL6123 | 0.92 | NPY5R (0.42) | NPY5RFASNMAPK1EPHX2ACHE | |
| SCHEMBL11909133 | 0.89 | HCAR3 (0.43) | MAPK1EPHX2L3MBTL1HCAR3KMT2A | |
| SCHEMBL11909130 | 0.89 | HCAR3 (0.43) | MAPK1EPHX2L3MBTL1HCAR3KMT2A | |
| SCHEMBL6261 | 0.88 | KAT2B (0.44) | L3MBTL1HCAR3KMT2AKCNMA1MAPT | |
| SCHEMBL6263 | 0.88 | KAT2B (0.44) | L3MBTL1HCAR3KMT2AKCNMA1MAPT | |
| SCHEMBL6280 | 0.87 | STAT3 (0.54) | MAPK1KMT2AMAPTSTAT3 | |
| SCHEMBL6282 | 0.87 | STAT3 (0.54) | MAPK1KMT2AMAPTSTAT3 | |
| SCHEMBL6635 | 0.85 | KMT2A (0.52) | FASNMAPK1HCAR3KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |