Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261 | 1.00 | KAT2B (0.44) | KAT2BL3MBTL1MAPTTRPV1ALDH1A1 | |
| SCHEMBL6905 | 0.92 | KAT2B (0.43) | KAT2BMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6903 | 0.92 | KAT2B (0.43) | KAT2BMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11909344 | 0.89 | KAT2B (0.46) | KAT2BL3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL11909340 | 0.89 | KAT2B (0.46) | KAT2BL3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL5906 | 0.88 | NPY5R (0.42) | L3MBTL1MAPTHCAR3KCNMA1KMT2A | |
| SCHEMBL5904 | 0.88 | NPY5R (0.42) | L3MBTL1MAPTHCAR3KCNMA1KMT2A | |
| SCHEMBL7661 | 0.87 | ALDH1A1 (0.51) | MAPTTRPV1ALDH1A1NPC1RAB9A | |
| SCHEMBL7663 | 0.87 | ALDH1A1 (0.51) | MAPTTRPV1ALDH1A1NPC1RAB9A | |
| SCHEMBL6635 | 0.85 | KMT2A (0.52) | KAT2BMAPTHCAR3RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |