Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.62 |
| ▸ | NOS1 | P29475 | 1/20 | 0.62 |
| ▸ | NOS2 | P35228 | 1/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215368 | 0.91 | NOS3 (0.55) | NOS3NOS1NOS2ACP1HRH2 | |
| SCHEMBL1913776 | 0.84 | NOS3 (0.58) | NOS3NOS1NOS2ACP1HRH2 | |
| SCHEMBL6067773 | 0.83 | RIPK1 (0.60) | NOS3NOS1NOS2ACP1UHRF1 | |
| SCHEMBL6067767 | 0.77 | NOS3 (1.00) | NOS3NOS1NOS2 | |
| SCHEMBL6067765 | 0.77 | NOS3 (0.69) | NOS3NOS1NOS2UHRF1LCK | |
| SCHEMBL5212896 | 0.76 | RIPK1 (0.60) | NOS3NOS1NOS2ACP1LCK | |
| SCHEMBL14062185 | 0.73 | RAD52 (0.53) | ACP1HRH2HRH1HRH3UHRF1 | |
| SCHEMBL1677886 | 0.72 | NOS3 (0.88) | NOS3NOS1NOS2 | |
| SCHEMBL6067758 | 0.71 | CLK1 (0.53) | CLK1HRH3MEN1KMT2ARAD52 | |
| SCHEMBL1677883 | 0.71 | NOS3 (0.62) | NOS3NOS1NOS2UHRF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141595-B2 | Amino benzothiazole compounds with NOS inhibitory activity | NEURAXON INC. (CA) | 2006-11-28 | — | — | US | disclosed |
| US-20050209291-A1 | N-(2-Amino-benzothiazol-6-yl)-ethylthiocarboximidamide or other amino benzothiazole derivatives as neuroprotectants and for the treatment of neuropathic pain | NEURAXON INC. (CA) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209291-A1 | N-(2-Amino-benzothiazol-6-yl)-ethylthiocarboximidamide or other amino benzothiazole derivatives as neuroprotectants and for the treatment of neuropathic pain | GAP43, NLN, TRPV1 | NOS3 377/4885NOS1 670/4885NOS2 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.