Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 12/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6067914 | 0.87 | ABL1 (0.55) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6068369 | 0.83 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6067813 | 0.81 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6068144 | 0.81 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6068084 | 0.80 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6068260 | 0.79 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL6068315 | 0.79 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1556613 | 0.77 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL6067985 | 0.73 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA | |
| SCHEMBL1282532 | 0.72 | ABL1 (0.51) | NPC1RAB9ASMN1; SMN2ABL1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091227-B2 | Benzothiazole derivatives | ABBOTT GMBH & CO. KG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20030153568-A1 | Benzothiazole derivatives | BASF AKTIENGESELLSCHAFT LUDWIGSHAFEN, GERMANY | 2003-08-14 | — | — | US | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153568-A1 | Benzothiazole derivatives | TK1, FLT1, CDK1 | NPC1 3594/4885RAB9A 3285/4885SMN1; SMN2 4285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.