Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25494628 | 0.83 | LMNA (0.57) | ALDH1A1LMNAALOX12GAAMEN1 | |
| SCHEMBL12203607 | 0.82 | KMT2A (0.61) | ALDH1A1LMNAALOX12GAAMEN1 | |
| SCHEMBL6096417 | 0.80 | GAA (0.62) | ALDH1A1LMNAGAAIDO1MEN1 | |
| SCHEMBL6067984 | 0.80 | GAA (0.63) | ALDH1A1LMNAALOX12GAAMEN1 | |
| SCHEMBL6068221 | 0.79 | IDO1 (0.57) | EPHX2ALOX5ALDH1A1IDO1MAPT | |
| SCHEMBL6067808 | 0.78 | LMNA (0.61) | EPHX2ALOX5ALDH1A1LMNAALOX12 | |
| SCHEMBL10099725 | 0.77 | GAA (0.83) | ALDH1A1LMNAGAAIDO1MEN1 | |
| SCHEMBL13737508 | 0.76 | LMNA (0.63) | EPHX2ALDH1A1LMNAALOX12GAA | |
| SCHEMBL11206964 | 0.75 | CDK1 (0.68) | EPHX2ALDH1A1LMNAALOX12GAA | |
| SCHEMBL20529633 | 0.75 | SMN1; SMN2 (0.57) | ALDH1A1LMNAGAAIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115620-B2 | 1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | WYETH (US) | 2006-10-03 | — | — | US | disclosed |
| US-20030119890-A1 | 1,3-Disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | WYETH (US) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119890-A1 | 1,3-Disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | KCNJ2, KCNJ1, KCNN1 | EPHX2 3341/4885ALOX5 1220/4885ALDH1A1 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.