Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068521 | 0.86 | KDM4E (0.41) | HPGDALDH1A1CRHBPCRHR2KMT2A | |
| SCHEMBL6068805 | 0.71 | MAPT (0.41) | ALDH1A1KMT2ARXFP1MEN1GAA | |
| SCHEMBL6068240 | 0.70 | MAPT (0.40) | ALDH1A1KMT2ARXFP1MEN1KDM4E | |
| SCHEMBL6068481 | 0.70 | POLB (0.46) | HPGDALDH1A1CRHBPCRHR2KMT2A | |
| SCHEMBL6068681 | 0.69 | GABRA1 (0.39) | KMT2ARXFP1MEN1KDM4EMAPT | |
| SCHEMBL6068576 | 0.69 | GABRA1 (0.59) | ALDH1A1LMNAHSD17B10 | |
| SCHEMBL6068766 | 0.69 | GABRA1 (0.40) | ALDH1A1KMT2ARXFP1MEN1GAA | |
| SCHEMBL6068824 | 0.69 | MAPT (0.38) | ALDH1A1KMT2ARXFP1MEN1KDM4E | |
| SCHEMBL6068581 | 0.69 | PARP1 (0.45) | HPGDALDH1A1KDM4E | |
| SCHEMBL6068244 | 0.69 | RXFP1 (0.51) | ALDH1A1KMT2ARXFP1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |