Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 11/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 11/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068619 | 0.87 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068773 | 0.86 | RXFP1 (0.50) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068524 | 0.85 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068798 | 0.83 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068562 | 0.83 | RXFP1 (0.49) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068552 | 0.83 | RXFP1 (0.49) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068576 | 0.82 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6068830 | 0.80 | RXFP1 (0.50) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068240 | 0.76 | MAPT (0.40) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068550 | 0.73 | RXFP1 (0.47) | RXFP1POLBTP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |