Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463512 | 0.84 | PDE7A (0.47) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL11464659 | 0.84 | PDE7A (0.47) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL15902849 | 0.83 | PDE7A (0.46) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL13115676 | 0.80 | DDAH1 (0.48) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL11717350 | 0.80 | MEN1 (0.42) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL15902842 | 0.80 | PDE7A (0.43) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL15903038 | 0.80 | MAOA (0.55) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL15903377 | 0.80 | TDP1 (0.45) | PDE7ACYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL7264531 | 0.79 | MEN1 (0.44) | PDE7AMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL7909790 | 0.79 | MEN1 (0.44) | PDE7AMEN1KMT2ACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081461-B1 | Quinazoline compounds and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2006-07-25 | — | — | US | disclosed |
| CN-1391561-A | Quinazoline compounds and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218356-A1 | QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021594-A1 | QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |