Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 19/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068562 | 0.85 | RXFP1 (0.49) | MEN1KMT2ARXFP1 | |
| SCHEMBL6068326 | 0.83 | GABRA1 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068576 | 0.83 | GABRA1 (0.59) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068548 | 0.82 | MAPT (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068711 | 0.82 | GABRA1 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068712 | 0.82 | GABRA1 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068549 | 0.80 | MEN1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068681 | 0.78 | GABRA1 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7421406 | 0.76 | GABRA1 (0.70) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6068706 | 0.73 | POLB (0.36) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |