Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068576 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6068681 | 0.83 | GABRA1 (0.39) | MEN1KMT2AKDM4EMAPTGABRA1 | |
| SCHEMBL6068326 | 0.81 | GABRA1 (0.62) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL6068643 | 0.81 | KMT2A (0.37) | MEN1KMT2AKDM4EMAPTGABRA1 | |
| SCHEMBL6068720 | 0.80 | GABRG2 (0.49) | MEN1KMT2AGABRA1GABRG2GABRB3 | |
| SCHEMBL6068711 | 0.80 | GABRA1 (0.46) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL6068712 | 0.80 | GABRA1 (0.46) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL7479320 | 0.76 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6068706 | 0.73 | POLB (0.36) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL6068331 | 0.71 | RXFP1 (0.36) | MEN1KMT2AKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |
| EP-1242423-A1 | SUBSTITUTED 1,2,3-TRIAZOLO 1,5-a]QUINAZOLINES FOR ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044250-A1 | SUBSTITUTED 1,2,3-TRIAZOLO[1,5-a]QUINAZOLINES FOR ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |