Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | CASP3 | P42574 | 1/20 | 0.71 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.71 |
| ▸ | MITF | O75030 | 1/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069212 | 0.84 | NPC1 (0.81) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL5532304 | 0.84 | NPC1 (0.95) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL3663640 | 0.84 | NPC1 (1.00) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL6069294 | 0.83 | NR4A2 (0.73) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL6068492 | 0.81 | NPC1 (0.76) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11646682 | 0.81 | NPC1 (0.79) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL2482092 | 0.81 | NPC1 (1.00) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11409495 | 0.81 | NPC1 (1.00) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11420874 | 0.80 | NPC1 (0.85) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11420574 | 0.80 | NPC1 (0.85) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053219-B2 | Isoxazolopyridone derivatives and their use | BANYU PHARMACEUTICAL CO. LTD. (JP) | 2006-05-30 | — | — | US | disclosed |
| US-20040176407-A1 | Novel isoxazolopyridone derivatives and their use | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-09-09 | — | — | US | disclosed |
| EP-1408042-A1 | NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND USE THEREOF | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176407-A1 | Novel isoxazolopyridone derivatives and their use | GRIN2A, GRM2, GRM1 | NPC1 657/4885RAB9A 756/4885CASP3 4305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.