Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23019763 | 1.00 | GAA (0.61) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL2776947 | 0.84 | SMN1; SMN2 (0.68) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL2776948 | 0.84 | SMN1; SMN2 (0.68) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL16563402 | 0.84 | SMN1; SMN2 (0.68) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL15164585 | 0.81 | GAA (0.58) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7440691 | 0.81 | GAA (0.53) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7440698 | 0.81 | GAA (0.53) | GAAMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL20677082 | 0.77 | KDM4E (0.58) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19402034 | 0.77 | KDM4E (0.58) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11327459 | 0.77 | KDM4E (0.58) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141672-B2 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2006-11-28 | — | — | US | disclosed |
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-07-29 | — | — | US | disclosed |
| US-6699896-B1 | METABOLIC DISORDERS, ANTIDIABETIC AGENTS; OBESITY | WYETH | 2004-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, GCKR | GAA 1042/4885MEN1 4616/4885KMT2A 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.