Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.71 |
| ▸ | PRKCB | P05771 | 7/20 | 0.71 |
| ▸ | PRKCA | P17252 | 6/20 | 0.71 |
| ▸ | PRKCG | P05129 | 7/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682932 | 0.87 | GSK3B (0.67) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL3774109 | 0.86 | GSK3B (0.66) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL2955502 | 0.86 | PRKCA (0.54) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL13670446 | 0.85 | GSK3B (0.65) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL4740834 | 0.85 | GSK3B (0.65) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL4677124 | 0.84 | GSK3B (0.64) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL1127716 | 0.84 | GSK3B (0.64) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL3773898 | 0.83 | GSK3B (1.00) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL1127978 | 0.83 | GSK3B (0.63) | GSK3BPRKCBPRKCAPRKCGPRKCD | |
| SCHEMBL2955240 | 0.83 | GSK3B (0.57) | GSK3BPRKCBPRKCAPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6987110-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-17 | — | — | US | disclosed |
| US-20040059113-A1 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059113-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | GSK3B 880/4885PRKCB 55/4885PRKCA 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.