Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21230658 | 0.84 | KDM4E (0.59) | IKBKBKDM4EKMT2AGFERRXFP1 | |
| SCHEMBL17774946 | 0.82 | IKBKB (0.49) | IKBKBKDM4EKMT2AGFERRXFP1 | |
| SCHEMBL17779229 | 0.78 | IKBKB (0.45) | IKBKBKDM4EGFERMAPTTDP1 | |
| SCHEMBL17774947 | 0.78 | IKBKB (0.45) | IKBKBKDM4EKMT2AGFERRXFP1 | |
| SCHEMBL19788692 | 0.78 | IKBKB (0.45) | IKBKBKDM4EKMT2AGFERRXFP1 | |
| SCHEMBL13030242 | 0.77 | IKBKB (0.51) | IKBKBPOLBALDH1A1MAPK1 | |
| SCHEMBL17774906 | 0.75 | ALDH1A1 (0.47) | IKBKBKDM4EKMT2AMAPTMEN1 | |
| SCHEMBL17774908 | 0.75 | ALDH1A1 (0.50) | IKBKBKDM4EKMT2AMAPTMEN1 | |
| SCHEMBL688411 | 0.75 | MAPT (0.56) | IKBKBKDM4EKMT2AGFERRXFP1 | |
| SCHEMBL5722013 | 0.74 | DGAT1 (0.35) | KDM4EKMT2AKDRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071219-B2 | Mono-acylated o-phenylendiamines derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-07-04 | — | — | US | disclosed |