Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | PTH1R | Q03431 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069353 | 0.74 | PLA2G1B (0.39) | PTH1RGCGRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL477421 | 0.71 | IDO1 (0.56) | IDO1TDO2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3056107 | 0.65 | MAPT (0.54) | IDO1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6068869 | 0.65 | CYP2A13 (0.56) | KMT2AMEN1MAPTLMNAMAPK1 | |
| Anthraquinone SCHEMBL2033678 | 0.64 | TERT (0.55) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL291122 | 0.64 | TERT (0.55) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28220955 | 0.64 | TYR (0.43) | IDO1TDO2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7283425 | 0.63 | CAMK2D (0.57) | IDO1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL10910157 | 0.63 | TERT (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11639238 | 0.63 | IDO1 (0.46) | IDO1TDO2CYP1A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6989382-B2 | Carbocycle based inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-01-24 | — | — | US | disclosed |
| EP-1556355-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2005-07-27 | — | — | EP | disclosed |
| US-20040138273-A1 | Carbocycle based inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2004-07-15 | — | — | US | disclosed |
| WO-2004037791-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138273-A1 | Carbocycle based inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, GSKIP | IDO1 1572/4885TDO2 2062/4885PTH1R 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.