Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 7/20 | 0.50 |
| ▸ | CHUK | O15111 | 7/20 | 0.50 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069652 | 0.90 | CDK2 (0.62) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL6070028 | 0.88 | SYK (0.46) | MKNK1IKBKBCHUKIKBKGCDK2 | |
| SCHEMBL6070502 | 0.88 | CAMK2D (0.46) | MKNK1IKBKBCHUKIKBKGSYK | |
| SCHEMBL6069779 | 0.84 | JAK2 (0.57) | CDK2CDK1PTK2CDK8CCNT1 | |
| SCHEMBL6070155 | 0.84 | CAMK2D (0.61) | IKBKBCHUKIKBKGCDK2CCNT1 | |
| SCHEMBL6070419 | 0.81 | AURKA (0.52) | IKBKBCHUKIKBKGCDK2SYK | |
| SCHEMBL6070706 | 0.79 | CDK1 (0.51) | CDK2CDK1SYK | |
| SCHEMBL6070167 | 0.78 | SYK (0.51) | CDK2CDK1SYK | |
| SCHEMBL14063912 | 0.78 | IKBKB (0.64) | MKNK1IKBKBCHUKCCNCCDK8 | |
| SCHEMBL3048434 | 0.77 | IKBKB (0.66) | MKNK1IKBKBCHUKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |