Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070502 | 0.91 | CAMK2D (0.46) | SYK | |
| SCHEMBL6070706 | 0.91 | CDK1 (0.51) | SYKCDK1CDK2 | |
| SCHEMBL6069652 | 0.88 | CDK2 (0.62) | SYKCDK1CDK2JAK2 | |
| SCHEMBL6070820 | 0.83 | SYK (0.44) | SYKCDK2JAK2 | |
| SCHEMBL6070028 | 0.82 | SYK (0.46) | SYKCDK1CDK2 | |
| SCHEMBL6069930 | 0.79 | KDR (0.52) | SYKCDK1CDK2JAK2 | |
| SCHEMBL6070287 | 0.78 | KDR (0.44) | SYKJAK2 | |
| SCHEMBL6070034 | 0.78 | MKNK1 (0.55) | SYKCDK1CDK2 | |
| SCHEMBL6071031 | 0.78 | KDR (0.43) | SYKJAK2 | |
| SCHEMBL6069976 | 0.77 | CDK2 (0.59) | CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |