Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 11/20 | 0.43 |
| ▸ | CDK1 | P06493 | 5/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070380 | 0.92 | KDR (0.39) | FLT1FLT4KDRCDK2IGF1R | |
| SCHEMBL6070303 | 0.91 | FLT1 (0.47) | FLT1FLT4KDRCDK2IGF1R | |
| SCHEMBL6070201 | 0.88 | SYK (0.41) | KDRCDK2CDK9SYKAURKA | |
| SCHEMBL6069930 | 0.87 | KDR (0.52) | FLT1FLT4KDRCDK2IGF1R | |
| SCHEMBL6070012 | 0.85 | KDR (0.63) | FLT1FLT4KDRCDK2IGF1R | |
| SCHEMBL6070198 | 0.83 | KDR (0.39) | FLT1FLT4KDRCDK2IGF1R | |
| SCHEMBL6070287 | 0.79 | KDR (0.44) | FLT1FLT4KDRSYK | |
| SCHEMBL6071031 | 0.79 | KDR (0.43) | FLT1FLT4KDRSYK | |
| SCHEMBL6069753 | 0.79 | KCNH2 (0.43) | KDRCDK2CDK9SYKAURKA | |
| SCHEMBL6070240 | 0.77 | KDR (0.54) | FLT1FLT4KDRFLT3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |