Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 6/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069930 | 0.92 | KDR (0.52) | KDRFLT1FLT4PKMNPSR1 | |
| SCHEMBL6070287 | 0.91 | KDR (0.44) | KDRFLT1FLT4PKMNPSR1 | |
| SCHEMBL6070240 | 0.90 | KDR (0.54) | KDRFLT1FLT4NR3C2SYK | |
| SCHEMBL6070015 | 0.86 | JAK2 (0.44) | KDRFLT1FLT4SYKGSK3B | |
| SCHEMBL6069836 | 0.85 | FLT1 (0.40) | KDRFLT1FLT4SYKPDGFRB | |
| SCHEMBL6070077 | 0.83 | JAK2 (0.45) | KDRFLT1FLT4SYKGSK3B | |
| SCHEMBL6070012 | 0.83 | KDR (0.63) | KDRFLT1FLT4PDGFRBABL1 | |
| SCHEMBL6069873 | 0.82 | KDR (0.53) | KDRFLT1FLT4SYKPDGFRB | |
| SCHEMBL6070296 | 0.79 | FLT1 (0.46) | KDRFLT1FLT4SYK | |
| SCHEMBL6070380 | 0.78 | KDR (0.39) | KDRFLT1FLT4SYKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109204-B2 | controlling signal transduction; anticancer agents, antitumor agents, atherosclerosis, vision defects, antidiabetic agents, antiinflammatory agents | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |